They are a vicious international quartet of criminals known as "The Big Four". Number One was a brilliant Chinese, the greatest criminal brain of all time; Number Two was a USAmerican multi-millionaire; Number Three was a beautiful Frenchwoman scientist; and Number Four was "the destroyer," the ruthless murderer with a genius for disguise, whose business it was to remove those who interfered with his masters plans. These four, working together, is a partnership with one simple goal, establish world dominance with murders.

Belgian detective Hercule Poirot was preparing for a voyage to South America when an uninvited guest, coated from head to foot in mud, stood at his doorway, collapsed, then recovered long enough to scribble the number four on a piece of paper. Now, "The Big Four" pursues eliminate the only man who can foil them: Hercule Poirot. It's up to Poirot and his faithful assistant Hastings to follow the clues and stop the deadly cabal from achieving its devastating end. But do they really avoid the Grim Reaper? In the most dangerous case of his career, the little detective will not be diverted by poison, a falling tree, electrocution, or a hit-and-run. Poirot appears to meet his end when a bomb explodes in his apartment. Hastings, devastated, vows to avenge him--but can he succeed without Poirot?